Fred Sanger: the giant of genomics

25 Nov

There was always something peaceful and satisfying about sitting with a well done sequencing gel / film and deciphering a gene.

We say goodbye to Fred Sanger, who died last week at age 95. Sanger is best known for the DNA sequencing method that bears his name. His process utilized dideoxyribonucleotides and PCR-like amplification of fragments. An animation of this sequencing method illustrates the principle.

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Last week, the biochemist Dr Fred Sanger died at the age of 95. He made an enormous contribution to research throughout the fields of biology and medicine, and we were all sad to hear the news.

Dr Sanger is best know for the breakthroughs that earned him two Nobel prizes: the development first of methods for determining the sequence of the amino acid building blocks in proteins, and later of the ‘Sanger method’ for sequencing DNA. He was not a cancer researcher — he tested his protein sequencing method on the hormone insulin, and applied his DNA sequencing method to simple viruses — but the methods that he devised have enabled a revolution in our understanding of diseases like cancer. Sanger sequencing…

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Posted by on November 25, 2013 in Uncategorized


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