I’ve had a question about Ebola posted on the StackExchange Biology page for some time without getting any answers. Basically, I was wondering about how antibody responses to Ebola can drive either sterilizing immunity (the goal) or actually improve the virus’s entry into host cells (a big problem). The idea that Ebola antibodies may be detrimental to the host was first raised by Baize et al, and my question is how this has impacted efforts to develop an effective vaccine. For background, I’ve written about this topic previously.
If anyone knows what the current thinking is in this area, please point them my way.