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An Ebola Question

Olytico-Question-Mark-1024x576I’ve had a question about Ebola posted on the StackExchange Biology page for some time without getting any answers. Basically, I was wondering about how antibody responses to Ebola can drive either sterilizing immunity (the goal) or actually improve the virus’s entry into host cells (a big problem). The idea that Ebola antibodies may be detrimental to the host was first raised by Baize et al, and my question is how this has impacted efforts to develop an effective vaccine. For background, I’ve written about this topic previously.

If anyone knows what the current thinking is in this area, please point them my way.

 
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Posted by on September 4, 2015 in Uncategorized

 

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Magic Bullets

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from SAFC global

I just saw that the most recent issue of Science is highlighting a favorite topic of mine, antibody-mediated therapy and B cell biology. I’ve done work in both of these (related) fields in the past and remain an advocate of antibody-tageting of therapies using drug conjugates (e.g. trastuzumab–DM1) or initiating cell-specific effects simply by binding (e.g. anti-CD20). 

In the early 20th century, Paul Ehrlich coined the phrase “magische Kugel,” to describe antibodies as ‘magical’ proteins which could unerringly home in on targets to do a variety of things. Today, we can paint tumors with antibody conjugated with fluorescent dyes, deliver toxic chemicals to cells we wish to eliminate or simply activate / deactivate cells through targeting of receptor proteins.

I’m eager to get my hands on this issue and see what’s new (if anything) in the field and what products are currently in the pipeline of various biotech companies. 

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(I’m suddenly struck anew with the misery of not having access to Nature and other journals I’ve always had handy. I’m so glad I at least still have Science! )

 

 
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Posted by on September 15, 2013 in Uncategorized

 

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