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Magic Bullets

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from SAFC global

I just saw that the most recent issue of Science is highlighting a favorite topic of mine, antibody-mediated therapy and B cell biology. I’ve done work in both of these (related) fields in the past and remain an advocate of antibody-tageting of therapies using drug conjugates (e.g. trastuzumab–DM1) or initiating cell-specific effects simply by binding (e.g. anti-CD20). 

In the early 20th century, Paul Ehrlich coined the phrase “magische Kugel,” to describe antibodies as ‘magical’ proteins which could unerringly home in on targets to do a variety of things. Today, we can paint tumors with antibody conjugated with fluorescent dyes, deliver toxic chemicals to cells we wish to eliminate or simply activate / deactivate cells through targeting of receptor proteins.

I’m eager to get my hands on this issue and see what’s new (if anything) in the field and what products are currently in the pipeline of various biotech companies. 

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(I’m suddenly struck anew with the misery of not having access to Nature and other journals I’ve always had handy. I’m so glad I at least still have Science! )

 

 
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Posted by on September 15, 2013 in Uncategorized

 

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Bummed

I just found out that I can’t teach an intro to physical sciences course next semester. It turns out the college has standards. To be honest, I don’t have a background that demonstrates that I could teach the class (my degree is in Immunology, not physics), but I thought it might slide.

I’m way more bummed about this than I should be, which definitely communicates something. Perhaps I’ll use my newfound free time to spend some more time on monster.com…

In the mean time, here’s a video demonstrating the fact that gravity works on all objects the same even if one is a bullet fired parallel to the ground (perpendicular to the force of g) and the other is a bullet casing dropped down without any velocity perpendicular to g.

 
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Posted by on October 15, 2012 in Uncategorized

 

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